In vivo production of an anti-HIV antibody from primate hematopoietic cells by non-viral knock-in
Jack M.P. Castelli, Katrina Poljakov, Youngseo Jwa, Molly E. Cassidy, Matthew D. Gray, Jocelyn N. Sanchez Gaytan, Mark Enstrom, Jonathan D. Linton, Anthony Rongvaux, Justin J. Taylor, Jennifer E. Adair
This study shows non-viral gene editing in primate hematopoietic stem cells can produce anti-HIV antibodies in vivo with detectable titers.
bioRxiv · May 2, 2025 · PreprintImmunology