Structure-guided engineering of CCL27 enhances natural ligand CAR T-cells against CCR10 for multiple myeloma
Nikhil Chilakapati, Bonell Patiño-Escobar, Emily Y. Chen, Radhika Dalal, Jonathan de Montagnac, Haley Johnson, Amrik S. Kang, Naomi Akagi, Emilio Ramos, Paul J. Phojanakong, Fernando Salangsang, Yan Zeng, Ajai Chari, Alfred Chung, Anupama Deepa Kumar, , Arun P. Wiita
This paper engineers CCL27 mutants to enhance CAR T-cell efficacy against multiple myeloma by targeting CCR10, achieving results comparable to BCMA CAR-Ts.
bioRxiv · Aug 19, 2025 · PreprintCancer Biology