Author

Emily Y. Chen

Fred Hutch Cancer CenterPrimary ORCID profile (0000-0002-5972-798X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Emily Y. CheniD1 paper · Berg (United States)

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Ajai ChariiD· 1 shared Alexander H.C.W. Agopyan-MiuiD· 1 shared Alfred ChungiD· 1 shared Amrik S. KangiD· 1 shared Anupama Deepa Kumar· 1 shared Arun P. WiitaiD· 1 shared Aude G. ChapuisiD· 1 shared Benjamin G. BarwickiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

Ajai ChariORCID

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Author profile →

3 papers

Recent·Most cited

Structure-guided engineering of CCL27 enhances natural ligand CAR T-cells against CCR10 for multiple myeloma

Nikhil Chilakapati, Bonell Patiño-Escobar, Emily Y. Chen, Radhika Dalal, Jonathan de Montagnac, Haley Johnson, Amrik S. Kang, Naomi Akagi, Emilio Ramos, Paul J. Phojanakong, Fernando Salangsang, Yan Zeng, Ajai Chari, Alfred Chung, Anupama Deepa Kumar, , Arun P. Wiita

This paper engineers CCL27 mutants to enhance CAR T-cell efficacy against multiple myeloma by targeting CCR10, achieving results comparable to BCMA CAR-Ts.

bioRxiv · Aug 19, 2025 · PreprintCancer Biology

Overcoming immune evasion from post-translational modification of a mutant KRAS epitope to achieve TCR-T cell-mediated antitumor activity

Jihoon William Lee, Emily Y. Chen, Taylor Hu, Rachel Perret, Mary E. Chaffee, Tijana Martinov, Shwetha Mureli, Clara McCurdy, Lisa Anne Jones, Philip R. Gafken, Pritha Chanana, Yapeng Su, Aude G. Chapuis, Philip H Bradley, Thomas M. Schmitt, Philip D. Greenberg

Tumor cell methylation of KRASG12V epitope in HLA-A2 permits immune evasion, and new TCRs were generated to overcome this with engineered cell therapy.

bioRxiv · Sep 18, 2024 · PreprintImmunology

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Katelyn N. Benthall, Katherine R Cording, Alexander H.C.W. Agopyan-Miu, Corinna D. Wong, Emily Y. Chen, Helen S. Bateup

Cell Reports · Aug 1, 2021Peer-reviewedNeuroscience