Dissection of Major Depressive Disorder using polygenic risk scores for Schizophrenia in two independent cohort.
Heather C Whalley, Mark J Adams, Lynsey Hall, Toni-Kim Clarke, Ana Maria Fernandez-Pujals, Jude Gibson, Ella Wigmore, Jonathan Hafferty, Saskia P Hagenaars, Gail Davies, Archie Campbell, Caroline Hayward, Stephen M Lawrie, David Porteous, Ian Deary, Andrew M McIntosh
This study investigates the interaction between polygenic risk scores for schizophrenia and major depressive disorder (MDD) in two cohorts, finding reduced case-control differences in distress and neuroticism with higher schizophrenia risk.
Translational Psychiatry · Nov 1, 2016Peer-reviewedNeuroscience