Caroline Hayward

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals

The paper identifies 16 genetic loci interacting with sleep duration to influence glycemic traits in over 480,000 individuals, revealing distinct biological mechanisms for short and long sleep.

Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals

The paper performs genome-wide association studies on 439 high-abundance serum proteins in 15,035 Scottish individuals, identifying 1,553 SNP signals and 13 putative causal protein-outcome associations.

Rheumatoid Arthritis-associated IgG N-glycan agalactosylation diminishes neutrophilic inflammation by reducing FcgammaR binding and downstream signaling

This study shows that agalactosylated IgG N-glycans in RA reduce neutrophilic inflammation by decreasing FcγR binding and downstream signaling, suggesting they may act as a compensatory anti-inflammatory mechanism.

Separating direct, indirect and parent-of-origin genetic effects in the human population

The paper introduces JODIE, a model to estimate direct, indirect, and parent-of-origin genetic effects on height, BMI, and educational attainment using family trios from two biobanks.

Sex differences in the genetic basis of human recombination within 190,000 parent-child pairs

This study identifies 58 genomic regions associated with meiotic recombination, 24 of which are sex-specific, and finds a moderate genetic correlation between male and female recombination rates.

Limited overlap between genetic effects on disease susceptibility and disease survival

The paper compares genetic effects on disease susceptibility and progression, finding limited overlap and suggesting larger samples or different progression measures are needed.

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function

The paper identifies 52 genome-wide associations for urinary metabolites and finds causal relationships between eGFR and 13 metabolites.

Family-GWAS reveals effects of environment and mating on genetic associations

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

The paper develops epigenetic scores for GDF15 and NT-proBNP levels, showing associations with disease risks and brain health traits in two cohorts.

Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability

This study shows that rare CNVs and PRS-IQ increase ASD risk independently of their effects on cognitive ability, suggesting ASD risk and cognitive ability are distinct outcomes of these variants.

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

Mapping of the gene network that regulates glycan clock of ageing

The paper identifies 16 genomic loci associated with IgG galactosylation through GWAS and validates three genes using CRISPR/dCas9 in an in vitro system.

Methylome-wide association studies of traumatic injury identifies differential DNA methylation of synaptic plasticity and GABAergic-signalling.

The paper identifies differential DNA methylation patterns associated with traumatic injury in individuals with MDD compared to controls, highlighting synaptic plasticity and GABAergic-signalling pathways.

Mapping pQTLs of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and novel therapeutic targets

The paper identifies pQTLs for 91 plasma proteins, finds novel associations, and uses MR to uncover causal roles in immune-mediated diseases, suggesting new therapeutic targets.

Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy

This study identifies fetal and maternal GDF15 as key factors in pregnancy-related nausea and vomiting, showing their roles in disease risk and severity.

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

Refining epigenetic prediction of chronological and biological age

The paper refines epigenetic predictors of chronological and biological age using large-scale EWAS and external validation, improving cAge prediction and outperforming existing bAge predictors.

Phenome-wide analysis identifies parent-of-origin effects on the human methylome associated with changes in the rate of aging

The paper identifies parent-of-origin effects on the methylome linked to aging rates by analyzing CpG methylation in a large family cohort.

Blood-based epigenome-wide analyses on the prevalence and incidence of nineteen common disease states

The paper conducts blood-based epigenome-wide association studies on 19 disease states, identifying novel CpG-disease associations and highlighting poor replication in existing literature.

Exome sequencing reveals aggregates of rare variants in glycosyltransferase and other genes influencing immunoglobulin G and transferrin glycosylation

The paper uses exome sequencing to identify rare variants in glycosyltransferase genes affecting transferrin and IgG glycosylation, linking them to disease-related traits.

Genome-wide association study reveals loci with sex-specific effects on plasma bile acids

The paper identifies sex-specific genetic loci associated with plasma bile acid levels using GWAS in a population-based cohort.

Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways

This study identifies 400+ genetic loci associated with circulating metabolic traits and highlights pleiotropy and novel disease pathways.

Investigating the contributions of circadian pathway and insomnia risk genes to autism and sleep disturbances

The paper investigates how copy number variants in circadian pathway and insomnia risk genes contribute to ASD risk and sleep disturbances in children with ASD.

Characterisation and Genetic Architecture of Major Depressive Disorder Subgroups Defined by Weight and Sleep Changes

This study characterizes MDD subgroups based on weight and sleep changes, finding distinct clinical and genetic profiles, including novel associations with epilepsy and immunometabolic genes.

Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

The paper identifies DNA methylation and proteomic markers associated with brain health through integrated methylome and phenome analyses.

Same role but different actors: genetic regulation of post-translational modification of two distinct proteins

The paper identifies genetic loci regulating glycosylation of transferrin and IgG, finding both shared and protein-specific associations and proposing tissue-specific transcription factor regulation.

The influence of biological and statistical properties of CpGs on epigenetic predictions of eighteen traits

This study evaluates how biological and statistical properties of CpGs affect epigenetic predictions for eighteen traits, showing that CpG methylation QTL status and beta-value distribution influence prediction accuracy.

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

This study identifies eight novel genetic signals associated with asthma-COPD overlap through a genome-wide association analysis involving multiple cohorts.

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

The paper develops eleven omics-based biological age clocks with strong correlations to chronological age and shows their association with disease risk.