Jude Gibson

The paper investigates associations between polygenic risk scores for schizophrenia, psychotic-like experiences, and structural brain network properties in healthy UK Biobank participants.

This paper conducts GWAS on two epigenetic age acceleration measures, identifying genetic variants and genes associated with each, and highlighting differences in their genetic architectures.

The paper identifies a neurobiological distinction in MDD subtypes based on SCZ polygenic risk, showing varying RACC thickness differences between MDD cases and controls.

A meta-analysis of 807,553 people from 23andMe, UK Biobank and PGC finds 102 depression variants. 87 of them replicate in 1,306,354 individuals, and heritability is enriched in prefrontal brain regions.

The paper replicates 55,000 DNA methylation QTLs using two cohorts and finds enrichment of trans mQTLs in specific genomic regions and complex traits.

This study conducts a GWAS on depression phenotypes in UK Biobank, identifying genetic variants enriched in excitatory synaptic pathways.

This study examines the association between polygenic risk scores for Major Depressive Disorder derived from the NETRIN1 pathway and whole-genome variants with white matter microstructure in the UK Biobank.

This study performs genome-wide meta-analyses of depression in two large cohorts, finding one significant locus and suggesting larger sample sizes may be more informative than phenotypic stratification.

The paper examines the relationship between DNA methylation age acceleration and Alzheimer’s disease risk factors, finding significant associations with BMI, cholesterol ratios, socioeconomic status, and smoking behavior.

This study finds accelerated epigenetic ageing in major depressive disorder (MDD) cases compared to controls using the Horvath clock, partially mediated through BMI.

This study investigates shared genetic architecture between subcortical brain volumes and MDD using GWAS data from multiple cohorts, finding a non-significant positive genetic correlation for hippocampal volume.

This study examines the genetic overlap between major psychiatric disorders and brain structure in UK Biobank data but finds no significant associations.

This study investigates the interaction between polygenic risk scores for schizophrenia and major depressive disorder (MDD) in two cohorts, finding reduced case-control differences in distress and neuroticism with higher schizophrenia risk.

This study identifies genetic and environmental factors contributing to chronic pain and its link to major depressive disorder using data from Generation Scotland and UK Biobank.