An optimal set of inhibitors for Reverse Engineering via Kinase Regularization.
Scott Rata, Jonathan Scott Gruver, Natalia Trikoz, Alexander Lukyanov, Janelle S. Vultaggio, Michele Ceribelli, Craig J. Thomas, Taranjit S. Gujral, Marc W. Kirschner, Leonid Peshkin
The paper presents a dataset of kinase inhibitor profiles and introduces an improved method to identify key kinases involved in cellular phenotypes using quantitative assays and machine learning.
bioRxiv · Sep 26, 2020 · PreprintSystems Biology