Michele Ceribelli

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

This study identifies co-inhibition of XPO1 and EIF4A1 as a therapeutic strategy for mCRPC, showing synergistic antitumor effects at reduced drug doses.

This study identifies multiple epigenetic mechanisms that silence SSTR2 expression in PNETs, highlighting the role of DNMT3B, PRC complexes, histone demethylases, and chromatin remodelers, with potential therapeutic implications.

The paper presents a dataset of kinase inhibitor profiles and introduces an improved method to identify key kinases involved in cellular phenotypes using quantitative assays and machine learning.