Craig J. Thomas

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

The paper identifies that DUB inhibitors and RNF168-mediated ubiquitylation drive SLFN11 chromatin recruitment, particularly at promoters, and that this process is suppressed by TAK243.

This study identifies multiple epigenetic mechanisms that silence SSTR2 expression in PNETs, highlighting the role of DNMT3B, PRC complexes, histone demethylases, and chromatin remodelers, with potential therapeutic implications.

This paper introduces PERCEPTION, a framework using single-cell transcriptomics to predict cancer treatment response and resistance, outperforming bulk expression-based methods in clinical trials.

The paper presents a dataset of kinase inhibitor profiles and introduces an improved method to identify key kinases involved in cellular phenotypes using quantitative assays and machine learning.

This study shows that targeting Nlgn3 secretion via ADAM10 inhibitors can block high-grade glioma growth in mouse models.