Passenger DNA alterations reduce cancer fitness in cell culture and mouse models
Christopher D McFarland, Julia A Yaglom, Jonathan W Wojtkowiak, Jacob G Scott, David L Morse, Michael Y Sherman, Leonid A Mirny
This study shows that increasing passenger DNA alterations in cancer cells reduces their fitness, slows tumor growth, and may serve as a biomarker for tumor aggressiveness and therapy response.
bioRxiv · Sep 8, 2015 · PreprintCancer Biology