Author

Leonid A Mirny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:Hi-C· 1

Frequent Co-Authors

Anton GoloborodkoiD· 1 shared Carolyn Lu· 1 shared Christopher D McFarland· 1 shared Christopher Dennis McFarland· 1 shared David L Morse· 1 shared Geoffrey FudenbergiD· 1 shared Jacob G Scott· 1 shared Jonathan W Wojtkowiak· 1 shared

Activity by Year

2014-2016 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperGenomics

Anton GoloborodkoORCID

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3 papers

Recent·Most cited

Formation of Chromosomal Domains by Loop Extrusion

Geoffrey Fudenberg, Maxim Imakaev, Carolyn Lu, Anton Goloborodko, Nezar Abdennur, Leonid A Mirny

This paper proposes that loop extrusion by cohesins and boundary proteins like CTCF forms Topologically Associating Domains (TADs) through dynamic loop creation and stabilization.

Cell Reports · May 1, 2016Peer-reviewedGenomics

Passenger DNA alterations reduce cancer fitness in cell culture and mouse models

Christopher D McFarland, Julia A Yaglom, Jonathan W Wojtkowiak, Jacob G Scott, David L Morse, Michael Y Sherman, Leonid A Mirny

This study shows that increasing passenger DNA alterations in cancer cells reduces their fitness, slows tumor growth, and may serve as a biomarker for tumor aggressiveness and therapy response.

bioRxiv · Sep 8, 2015 · PreprintCancer Biology

A tug-of-war between driver and passenger mutations in cancer and other adaptive processes

Christopher Dennis McFarland, Leonid A Mirny, Kirill S Korolev

The paper develops a stochastic model of mutation dynamics in cancer, showing how driver and passenger mutations interact to influence tumor progression and treatment outcomes.

bioRxiv · Feb 26, 2014Cancer Biology