The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cellsagainst cell-associated antigens by XCR1+ type 1 DCs in vivo.
Naman Tandon, Enric Gutiérrez-Martínez, Pierre Bourdely, Giorgio Anselmi, Jordan Denisot, Yohan Gerber-Ferder, Julie Helft, Marcelle Bens, Loredana Saveanu, Pierre Guermonprez
This study identifies Rab32 as essential for cDC1-mediated cross-priming of CD8 T cells against cell-associated antigens in vivo, but not ex vivo.
bioRxiv · May 3, 2025 · PreprintImmunology