Author

Julie Helft

Centre National de la Recherche ScientifiqueORCID 0000-0002-2733-1972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:spatial transcriptomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Giorgio AnselmiiD· 2 shared Loredana SaveanuiD· 2 shared Pierre BourdelyiD· 2 shared Pierre GuermonpreziD· 2 shared Yohan Gerber-FerderiD· 2 shared Aboubacar Sidiki K. CoulibalyiD· 1 shared Agathe OkiD· 1 shared Amaury LerusteiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersImmunology

Giorgio AnselmiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity

Louise Gorline, Fillipe Luiz Rosa Do Carmo, Pierre Bourdely, Jérémie Bornères, Nathan Vaudiau, Aurélie Semervil, Mathias Vétillard, Aboubacar Sidiki K. Coulibaly, Natacha Jugniot, Agathe Ok, Mathilde Bausart, Oriane Fiquet, Marine Andrade, Dicken Fardol, Ikrame Haddar, , Pierre Guermonprez

The paper demonstrates that delivering FLT3L with CXCL9 and CCL5 enhances cDC1 infiltration and antitumor immunity in mice and humanized models.

Nature Communications · Dec 30, 2025Peer-reviewedImmunology

Myeloid reprogramming by poly(I:C) recruits progenitor-exhausted CD8+ T cells and sensitizes rhabdoid tumors to PD-1 blockade

Valeria Sandoval Manríquez, Sofia Cavada-Silva, Kévin Beccaria, Leticia Laura Niborski, Amaury Leruste, Wilfrid Richer, Mathias Vandenbogaert, Zhi‐Yan Han, Christine Sedlik, Jordan Denizeau, Jérémy Mesple, Zoé Fusilier, Laëtitia Lesage, Jérémie D. Goldstein, Yohan Gerber-Ferder, , Eliane Piaggio

This study shows that poly(I:C) reprograms myeloid cells in rhabdoid tumors, enhancing CD8+ T cell infiltration and improving response to PD-1 blockade.

bioRxiv · Dec 29, 2025 · PreprintImmunology

The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cellsagainst cell-associated antigens by XCR1+ type 1 DCs in vivo.

Naman Tandon, Enric Gutiérrez-Martínez, Pierre Bourdely, Giorgio Anselmi, Jordan Denisot, Yohan Gerber-Ferder, Julie Helft, Marcelle Bens, Loredana Saveanu, Pierre Guermonprez

This study identifies Rab32 as essential for cDC1-mediated cross-priming of CD8 T cells against cell-associated antigens in vivo, but not ex vivo.

bioRxiv · May 3, 2025 · PreprintImmunology