ImmunologyNature CommunicationsPeer-reviewed
Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse
Shafat Ali, Anders Hayden Berg, Michifumi Yamashita…·S. Ananth Karumanchi
This study identifies BTN2A2 as a CD45RO ligand that enhances CD45 phosphatase activity, promoting Treg expansion and reducing Th17 cells, thereby ameliorating autoimmunity in mice and humans.