This study identifies BTN2A2 as a CD45RO ligand that enhances CD45 phosphatase activity, promoting Treg expansion and reducing Th17 cells, thereby ameliorating autoimmunity in mice and humans.

Nature Communications · Jan 8, 2026Peer-reviewedImmunology

The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits

Nancy Morones, Predrag Jovanović, Anna Magdalena Sanetra, Kaitlyn Jang, Nareg Keshishian, Zhihan Cui, Edward Novinbakht, Joshua J. Breunig, Anders Hayden Berg, Tamar Pirtskhalava, Selim Chaib, S. Ananth Karumanchi, Tamar Tchkonia, Kätlin Silm, James L. Kirkland, Celine Emmanuelle Riera

This study identifies SONAVP neuron hyperactivity as a driver of aging-related homeostatic deficits and suggests AVP signaling modulation as a therapeutic strategy.

bioRxiv · Nov 3, 2025 · PreprintPhysiology

Quinolinic acid metabolism may mitigate AKI to CKD transition

Marie Christelle Saadé, Afaf Saliba, Amanda J. Clark, Subrata Debnath, Shiqi Zhang, Nagarjunachary Ragi, Valerie Etzrodt, Rahil Alhumaidi, Kyle Q. Vu, Tao Yu, Esmeralda Trevino, Alejandra L Lorenzen, Guanshi Zhang, Anders Hayden Berg, Jason C. O’Connor, , Kumar Sharma

This study identifies quinolinic acid as a mediator of kidney injury and fibrosis, suggesting it as a potential therapeutic target for preventing AKI-to-CKD progression.

bioRxiv · Oct 10, 2025 · PreprintPathology