S. Ananth Karumanchi

This study examines the association between maternal and fetal HLA heterozygosity and preeclampsia risk in a large multi-ancestry cohort, finding protective and risk associations for specific HLA loci.

This study identifies BTN2A2 as a CD45RO ligand that enhances CD45 phosphatase activity, promoting Treg expansion and reducing Th17 cells, thereby ameliorating autoimmunity in mice and humans.

This study identifies SONAVP neuron hyperactivity as a driver of aging-related homeostatic deficits and suggests AVP signaling modulation as a therapeutic strategy.

The paper constructs an mRNA-seq atlas of human placenta across gestation, identifying extensive transcriptome changes from first to third trimester.

This study investigates whether genetic predisposition to medical conditions linked to preeclampsia risk increases preeclampsia risk, finding associations with diastolic blood pressure and BMI.

The paper uses single-cell RNA sequencing to analyze maternal-fetal interface cell types and identifies sex-specific differences in immune cell function and regulatory pathways.