ImmunologymSystemsPeer-reviewed
Timing matters in Macrophage / CD4+ T cell interactions: An agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals
Alexis Hoerter, Alexa Petrucciani, Jordan R. Bonifacio…·Elsje Pienaar
This paper develops an agent-based model to simulate immune responses to Mycobacterium tuberculosis infection, showing that early macrophage-CD4+ T cell interactions in latent TB infection reduce bacterial load through TNF and IFNγ mechanisms.
7 citations