Early Deprivation Impairs Perforant Pathway Connectivity and Contextual Memory in Adolescent Male Mice
Rafiad Islam, Jordon D. White, Tanzil Mahmud Arefin, Sameet S. Mehta, Xinran Liu, Baruh Polis, Lauryn Giuliano, Sahabuddin Ahmed, Christian Andrew Bowers, Jiangyang Zhang, Arie Kaffman
This study shows that early-life adversity impairs reelin-positive projections from the LEC to the dorsal hippocampus in male mice, leading to contextual memory deficits and structural changes.
bioRxiv · Aug 8, 2023 · PreprintNeuroscience