Author

Baruh Polis

Bar-Ilan UniversityORCID 0000-0002-3496-8250Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Abraham O. SamsoniD· 3 shared Hava Gil-HenniD· 3 shared Kolluru D. SrikanthiD· 3 shared Arie KaffmaniD· 2 shared Christian Andrew BowersiD· 2 shared Lauryn GiulianoiD· 2 shared Rafiad IslamiD· 2 shared Sahabuddin AhmediD· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Abraham O. SamsonORCID

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Author profile →

5 papers

Recent·Most cited

Transient Impairment in Microglial Function Causes Sex-Specific Deficits in Synaptic and Hippocampal Function in Mice Exposed to Early Adversity

Sahabuddin Ahmed, Baruh Polis, Sumit Jamwal, Basavaraju G. Sanganahalli, Zoë A. MacDowell Kaswan, Rafiad Islam, Dana Kim, Christian Andrew Bowers, Lauryn Giuliano, Thomas Biederer, Fahmeed Hyder, Arie Kaffman

This study shows that early adversity impairs microglial function in male mice, causing synaptic and behavioral deficits, while females show resilience through astrocytic compensation.

bioRxiv · Feb 14, 2024 · PreprintNeuroscience

Early Deprivation Impairs Perforant Pathway Connectivity and Contextual Memory in Adolescent Male Mice

Rafiad Islam, Jordon D. White, Tanzil Mahmud Arefin, Sameet S. Mehta, Xinran Liu, Baruh Polis, Lauryn Giuliano, Sahabuddin Ahmed, Christian Andrew Bowers, Jiangyang Zhang, Arie Kaffman

This study shows that early-life adversity impairs reelin-positive projections from the LEC to the dorsal hippocampus in male mice, leading to contextual memory deficits and structural changes.

bioRxiv · Aug 8, 2023 · PreprintNeuroscience

Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer's Disease Mice

Baruh Polis, Kolluru D. Srikanth, Vyacheslav Gurevich, Naamah Bloch, Hava Gil-Henn, Abraham O. Samson

The paper investigates the effect of arginase inhibition with norvaline on adult neurogenesis in Alzheimer's disease mice, finding increased neuronal survival and molecular markers of maturation.

International Journal of Molecular Sciences · Feb 8, 2020Peer-reviewedNeuroscience

L-Norvaline, a New Therapeutic Agent against Alzheimer s disease.

Baruh Polis, Kolluru D. Srikanth, Vyacheslav Gurevich, Hava Gil-Henn, Abraham O. Samson

This study evaluates L-norvaline's neuroprotective effects in an AD mouse model, finding it reverses cognitive decline and reduces beta-amyloidosis and microgliosis.

Neural Regeneration Research · May 9, 2019Peer-reviewedNeuroscience

L-norvaline reverses cognitive decline and synaptic loss in a murine model of Alzheimer’s disease

Baruh Polis, Kolluru D. Srikanth, Evan Elliott, Hava Gil-Henn, Abraham O. Samson

This study shows that L-norvaline improves spatial memory and reduces amyloid-beta in Alzheimer's mice by inhibiting arginase and S6K1 pathways.

Neurotherapeutics · Oct 1, 2018Peer-reviewedNeuroscience