Arie Kaffman

The paper shows that TREM2 deficiency contributes to impaired microglial pruning and hippocampal dysfunction in a mouse model of childhood deprivation, and that TREM2 overexpression can rescue these deficits.

This study investigates how erratic maternal care in mice affects attachment-like behavior, finding avoidant-like deficits in some tests but not others.

This study shows that early adversity impairs microglial function in male mice, causing synaptic and behavioral deficits, while females show resilience through astrocytic compensation.

This study shows that early-life adversity impairs reelin-positive projections from the LEC to the dorsal hippocampus in male mice, leading to contextual memory deficits and structural changes.

This paper uses computational modeling to show that early adversity increases stochasticity in the formation of structural brain networks in mice.