Endothelial expression of ZBTB16 protects against cardiac aging
Kathrin A. Stilz, Vincent Elvin Leonard, David Rodríguez Morales, Simone-Franziska Glaser, Veronica Larcher, Mariano Ruz Jurado, Pedro Felipe Malacarne, Nivethitha Manickam, Lukas Stefan Tombor, Wesley Tyler Abplanalp, Josefine Panthel, Haris Kujundzic, Ariane Fischer, Katja Schmitz, Oliver J Mueller, , Stefanie Dimmeler
This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.
bioRxiv · Oct 8, 2025 · PreprintCell Biology