Jaya Krishnan

The paper uses human heart organoids to model mitochondrial disease and identifies a drug that improves mitochondrial function and tissue contractility.

This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.

This study shows that HIF1α is essential for adipose tissue growth under normal conditions and in response to high-fat diets, by rechanneling metabolic intermediates into lipid synthesis.

This study identifies the lncRNA Sweetheart as essential for compensatory cardiac hypertrophy after myocardial injury, working synergistically with NKX2-5.

The paper identifies regulatory SNPs linked to CVDs and shows their impact on non-coding RNA expression and cardiac function in disease models.

This study identifies LINC00607 as an endothelial-specific lncRNA that supports angiogenic function by interacting with BRG1 to regulate chromatin accessibility and ERG target gene transcription.