FZD2 inhibits YAP and prevents cell cycle reentry in adult murine cardiomyocytes
Joseph A. Bisson, Pearl J. Quijada, Yves T. Wang, Janet K. Lighthouse, Jay-Christian Paul Helt, Eugene Kim, Edward E. Morrisey, Paul S. Brookes, Eric M. Small, Ethan David Cohen
This study shows FZD2 inhibits YAP and prevents adult murine cardiomyocytes from reentering the cell cycle, and its deletion improves heart function and reduces scarring after myocardial infarction.
bioRxiv · Jul 26, 2024 · PreprintCell Biology