Edward E. Morrisey

The paper constructs a single-cell atlas of PVOD across the lifespan, identifying endothelial dysfunction and molecular pathways as key drivers of the disease with potential therapeutic targets.

This paper identifies pulmonary neutrophils as the primary target of Abraxane in lung cancer and shows that its efficacy depends on complement pathway-mediated lung uptake.

This study shows that mechanical-nuclear signaling in alveolar fibroblasts influences lung regeneration by modulating transcriptional identity and epithelial repair after injury.

The paper shows that the cloacal outgrowth coordinates bladder and umbilical artery development through Shh and Wnt2 signals in humans and mice.

The paper creates a postnatal human lung developmental atlas to identify genes linked to chronic lung disease risk and shows COPD genetic risk is enriched in genes active during early postnatal endothelial development.

This study shows that alveolar epithelial type I cells propagate mechanical signals that affect lung homeostasis and disease states through intercellular communication.

The paper identifies Meibomian gland stem cell populations and mechanisms of aging using mouse models and finds Hh signaling regulates stem cell proliferation, with decreased Hh and EGF signaling in aged glands.

This study maps the temporal sequence of mouse lung regeneration after viral injury, identifying persistent injury-associated cell states and their role in alveolar niche repair.

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.

This study shows FZD2 inhibits YAP and prevents adult murine cardiomyocytes from reentering the cell cycle, and its deletion improves heart function and reduces scarring after myocardial infarction.

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

The paper constructs a single-cell reference atlas for human and mouse lung tissues to improve cell type annotation and data integration.

This study shows that FZD2 mutations cause limb defects by disrupting both canonical and non-canonical Wnt signaling, using genetic mouse models to establish causality in Robinow Syndrome and omodysplasia.

The paper describes the LungMAP Portal Ecosystem, a centralized resource integrating multi-omics and imaging data across species to enable standardized analysis of lung biology and disease.

The paper investigates how hyperactive mTOR in lung mesenchyme leads to endothelial dysfunction and pulmonary vascular remodeling in LAM.