Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development
Timothy J. Mead, Daniel R. Martin, Lauren W. Wang, Stuart A. Cain, Çağrı Güleç, Elisabeth Cahill, Joseph Mauch, Dieter Peter Reinhardt, Cecilia W. Lo, Clair Baldock, Suneel S. Apte
This study shows that proteolysis of fibrillin-2 by ADAMTS6 is essential for normal skeletal development, as its absence leads to skeletal defects and reduced aggrecan and cartilage link protein.
eLife · Apr 14, 2022Peer-reviewedDevelopmental Biology