Stuart A. Cain

The paper introduces MPP, a user-friendly R Shiny platform for quantitative proteomic analysis, demonstrating its ability to identify reproducible clusters and reveal biologically meaningful patterns.

This study uses hPSCs to model MED with MATN3 mutations, revealing altered matrix organisation and upregulated cholesterol biosynthesis pathway.

The paper identifies TIGIT interactors and shows that inhibitory TIGIT signaling requires both CD155 ligation and TCR activation in T cells.

This study shows that proteolysis of fibrillin-2 by ADAMTS6 is essential for normal skeletal development, as its absence leads to skeletal defects and reduced aggrecan and cartilage link protein.

This study shows that SIRT1 activation increases ECM gene expression but reduces GAG retention during hESC chondrogenesis, suggesting a complex role in cartilage development.

This paper develops an optogenetic system to control BMP signaling using blue light, enabling precise and dynamic activation in human cells.