Clair Baldock

This study uses hPSCs to model MED with MATN3 mutations, revealing altered matrix organisation and upregulated cholesterol biosynthesis pathway.

The paper identifies and validates binding epitopes in Twisted gastrulation (Tsg) that mediate interaction with Sog/Chordin, revealing an avidity-driven mechanism for BMP gradient formation.

This paper investigates how PTX3's quaternary structure enables HA crosslinking via interactions with HC1, revealing pH-dependent binding and structural flexibility.

The paper models the structure of Sog using AlphaFold and creates a sog knockout fly stock to study its function in Drosophila.

This study shows that proteolysis of fibrillin-2 by ADAMTS6 is essential for normal skeletal development, as its absence leads to skeletal defects and reduced aggrecan and cartilage link protein.