Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells
Marina Pavlou, Juliette Wohlschlegel, Josh Hahn, Lew Kaplan, Fred M Rieke, Michael B. Manookin, Isabel Ortuño‐Lizarán, Marlene Probst, Aric Prieve, Thomas A. Reh
This study shows that ASCL1 can reprogram adult and infant macaque Müller glia into retinal ganglion cell-like neurons using a modified vector cassette.
bioRxiv · Aug 21, 2025 · PreprintNeuroscience