Regulation of TCR-induced Transcriptional Kinetics by Interleukin 2-inducible T Cell Kinase (ITK) in CD8+ T cells
Josh Hunkins, Zoe K. Bedrosian, Uddeep Chaudhury, Alayna Rosales, Mary Jessamine Michaels, Masahiro Ono, Abhyudai Singh, Leslie J. Berg
This study shows ITK differentially regulates early and late TCR transcriptional responses by affecting the kinetics and termination of activation signals in CD8+ T cells.
bioRxiv · Sep 22, 2025 · PreprintImmunology