Cell-Specific Modulation of the Aryl Hydrocarbon Receptor by Kynurenine in Pulmonary Fibrosis Requires Microenvironmental Crosstalk
Hannah M. Carter, Benjamin C. Anderson, Rita Medina Costa, Joshua Franzen, Joshua Kurkonis, Kayla C. Jenkins, Rachel L. Zemans, Bethany B. Moore, Stephen J. Gurczynski
This study shows that kynurenine modulates AHR signaling in specific pulmonary cell types, with pathogenic effects requiring cell-cell interactions, not isolated cell responses.
bioRxiv · Jul 22, 2026 · PreprintImmunology