Rachel L. Zemans

The paper identifies a conserved profibrotic transitional state arising from alveolar and airway progenitors in fibrosis and shows its epigenetic regulation.

The paper shows that sepsis reprograms monocytes into a pro-inflammatory state and shifts their lineage toward neutrophil-like cells, increasing lung injury risk in survivors.

This study shows that kynurenine modulates AHR signaling in specific pulmonary cell types, with pathogenic effects requiring cell-cell interactions, not isolated cell responses.

The paper uses longitudinal single-cell RNA-seq to study lung fibrosis resolution, identifying pro- and anti-fibrotic pathways and cellular interactions during recovery.

This study uses photo-crosslinking to induce early fibrotic changes in ex vivo tissue, showing how matrix stiffening affects cell behavior and fibrosis progression.