Author

Joshua K. Kleam

The University of Texas Health Science Center at Tyler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Andy OmejeiD· 2 shared Guohua YiiD· 2 shared Mounika Duggineni· 2 shared Rajesh ManiiD· 2 shared Sitaramaraju AdduriiD· 2 shared Diego Rincón· 1 shared John J. DennehyiD· 1 shared José Alejandro BohórqueziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMicrobiology

Andy OmejeORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 26, 2026

Genomic Characterization and Therapeutic Potential of the Lytic Bacteriophage Curly against Klebsiella pneumoniae in Human Innate Immune Cells and a Murine Pneumonia Model

Mounika Duggineni, Sitaramaraju Adduri, Rajesh Mani…·Guohua Yi

This study characterizes a bacteriophage, Curly, against Klebsiella pneumoniae, showing its efficacy in reducing bacterial burden and inflammation in human cells and a mouse model.

DOI 10.64898/2026.08.25.747058

humanmouse

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MicrobiologybioRxivPreprintJan 29, 2025

Spatial transcriptomic analysis of HIV and tuberculosis coinfection in a humanized mouse model reveals specific transcription patterns, immune responses and early morphological alteration signaling

Sitaramaraju Adduri, José Alejandro Bohórquez, Rajesh Mani…·Guohua Yi

This study uses spatial transcriptomics to analyze HIV and tuberculosis coinfection in humanized mice, revealing distinct immune cell infiltration patterns and transcriptional signatures in early infection stages.

1 citation

mousespatial transcriptomics

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