Guohua Yi

Genomic Characterization and Therapeutic Potential of the Lytic Bacteriophage Curly against Klebsiella pneumoniae in Human Innate Immune Cells and a Murine Pneumonia Model

This study characterizes a bacteriophage, Curly, against Klebsiella pneumoniae, showing its efficacy in reducing bacterial burden and inflammation in human cells and a mouse model.

Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and 1 Mycobacterium tuberculosis in macrophages and humanized mice

This study shows that Sirt2 inhibition reduces HIV-1 and Mtb replication in macrophages and humanized mice, suggesting a dual therapeutic strategy.

Spatial transcriptomic analysis of HIV and tuberculosis coinfection in a humanized mouse model reveals specific transcription patterns, immune responses and early morphological alteration signaling

This study uses spatial transcriptomics to analyze HIV and tuberculosis coinfection in humanized mice, revealing distinct immune cell infiltration patterns and transcriptional signatures in early infection stages.