UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import
Tomer Shpilka, Yunguang Du, Qiyuan Yang, Andrew Melber, Nandhitha Uma Naresh, Joshua Lavelle, Sookyung Kim, Pengpeng Liu, Hilla Weidberg, Rui Li, Jun Yu, Lihua Julie Zhu, Lara I. Strittmatter, Cole M. Haynes
The paper shows that mitochondrial network expansion during development is controlled by the UPRmt pathway, which is influenced by protein synthesis and the mitochondrial import capacity of ATFS-1.
Nature Communications · Jan 20, 2021Peer-reviewedMolecular Biology