Yunguang Du

Impaired Endosomal Recycling of Signaling Receptors Activates an Extracellular UPR

The paper identifies a signaling pathway linking endosomal recycling impairment to activation of the mitochondrial unfolded protein response, promoting extracellular proteostasis.

LONP-1 deficiency causes dysregulated protein synthesis within mitochondria that is restored by mitoribosomal mutations

This study shows that LONP-1 deficiency disrupts mitochondrial protein synthesis and DNA replication in C. elegans, which is partially restored by mutations in mitochondrial ribosome proteins.

AMP accumulation during mitochondrial stress induces transcription of cytosolic and mitochondrial protein synthesis components via NHR-180

The paper identifies NHR-180 as a regulator of mitochondrial function and protein synthesis that can restore mitochondrial function in atfs-1(null) worms and mammalian models.

ATFS-1 regulates peroxisome assembly genes and protects both mitochondria and peroxisomes during peroxin perturbations

UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import

The paper shows that mitochondrial network expansion during development is controlled by the UPRmt pathway, which is influenced by protein synthesis and the mitochondrial import capacity of ATFS-1.