Cole M. Haynes

The paper identifies a signaling pathway linking endosomal recycling impairment to activation of the mitochondrial unfolded protein response, promoting extracellular proteostasis.

This study shows that LONP-1 deficiency disrupts mitochondrial protein synthesis and DNA replication in C. elegans, which is partially restored by mutations in mitochondrial ribosome proteins.

The paper identifies NHR-180 as a regulator of mitochondrial function and protein synthesis that can restore mitochondrial function in atfs-1(null) worms and mammalian models.

The paper shows that mitochondrial network expansion during development is controlled by the UPRmt pathway, which is influenced by protein synthesis and the mitochondrial import capacity of ATFS-1.