Lihua Julie Zhu

This study identifies IRS2 as a mediator of resistance to PI3K pathway inhibitors in PIK3CA mutant breast cancer by sustaining PI3K signaling through FOXO3-mediated regulation.

The paper introduces OTTR-CLASH, a method that improves the detection of miRNA-target interactions by using a modified RT and enhanced bioinformatics pipeline.

This study shows that delivering multiple cytokine and antigen mRNAs via nanoparticles can generate strong anti-tumor immunity against pancreatic cancer in mice.

This study shows that LONP-1 deficiency disrupts mitochondrial protein synthesis and DNA replication in C. elegans, which is partially restored by mutations in mitochondrial ribosome proteins.

This study shows that radiation resistance in TNBC enhances metastasis through RNA metabolism changes, specifically via HNRNPL-mediated circRNAs that regulate ITGβ3 expression.

The paper shows that dynamic phosphorylation of Hcm1 is essential for yeast fitness in chronic stress by modulating its activity and target gene expression.

This study shows that MYC and p53 alterations in prostate cancer cooperate via VEGF signaling to suppress T cell activity and immunotherapy responses, and that targeting VEGFR2 can enhance immunotherapy efficacy.

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

The paper identifies NHR-180 as a regulator of mitochondrial function and protein synthesis that can restore mitochondrial function in atfs-1(null) worms and mammalian models.

This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.

This study shows calcineurin (CN) helps yeast adapt to chronic stress through two distinct mechanisms involving Crz1 and Crz1-independent pathways.

The paper investigates chromatin changes in human endothelial cells under inflammatory stress using ATAC-seq and RNA-seq, finding correlations between chromatin accessibility and gene expression related to endothelial dysfunction.

This study identifies the role of stromal Hippo-YAP signaling in maintaining intestinal homeostasis by regulating stem cell niche function and epithelial regeneration.

This study optimizes the nuclear localization signal (NLS) of Cas12a to enhance editing efficiency in human primary cells without compromising specificity.

The paper shows that mitochondrial network expansion during development is controlled by the UPRmt pathway, which is influenced by protein synthesis and the mitochondrial import capacity of ATFS-1.

This study shows that EpoR signaling accelerates cell cycling and increases red cell size in mouse and human erythropoiesis, independent of HRI and not due to reticulocyte increase.

The paper introduces dagLogo, an R/Bioconductor package for identifying and visualizing differential amino acid group usage in proteomics data, showing improved performance in detecting conserved sequence patterns.

The paper maps nucleolus-associated domains (NADs) in mouse embryonic stem cells, revealing developmental differences in their characteristics compared to mouse embryonic fibroblasts.

GS-Preprocess simplifies GUIDE-seq analysis by converting standard Illumina sequencer output into compatible input for off-target profiling, enhancing accessibility and reducing costs.

This paper demonstrates that circular ssDNA donors improve HDR efficiency and reduce off-target integration compared to linear ssDNA donors in mammalian cells.

The paper identifies two distinct classes of Nucleolus-Associated Domains (NADs) in mouse fibroblasts using deep sequencing and a new tool, showing differences in chromatin features and gene expression.

The paper demonstrates that NmeCas9, a Cas9 ortholog, exhibits high-fidelity genome editing in human cells with minimal off-target effects and multiple PAM compatibility.

The paper traces the morphogenesis and transcriptome of early vascular smooth muscle cells in zebrafish using foxc1b as a marker.

C-BERST uses dCas9-APEX2 to map proteomes near genomic loci, identifying telomere and centromere-associated proteins.

This study shows that Ki-67 depletion in human cells slows S phase entry and disrupts Xi heterochromatin maintenance, with p21 playing a key role in these effects.