A knockout screening platform for interferon-stimulated genes in respiratory cells identifies LY6E as a dominant antiviral effector against coronaviruses
Caitlin I. Stoddard, Morgan L. Litchford, Kevin Sung, Rebecca Hutcheson, Joshua Marceau, Taylor Johnson, Akinobu Ota, Nell E. Baumgarten, Michael Gale, Julie M. Overbaugh
This study uses CRISPR-Cas9 to identify LY6E as an antiviral factor against coronaviruses in respiratory cells.
bioRxiv · Sep 23, 2026 · PreprintMicrobiology