Author

Caitlin I. Stoddard

University of California, San FranciscoORCID 0000-0002-2750-3228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Geeta J. NarlikariD· 2 shared Hiten D. MadhaniiD· 2 shared Julie M. OverbaughiD· 2 shared Kevin SungiD· 2 shared Phillip A. DumesiciD· 2 shared Sandra CataniaiD· 2 shared Akinobu OtaiD· 1 shared Ammar NasifiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMolecular Biology

Geeta J. NarlikarORCID

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4 papers

Recent·Most cited

A knockout screening platform for interferon-stimulated genes in respiratory cells identifies LY6E as a dominant antiviral effector against coronaviruses

Caitlin I. Stoddard, Morgan L. Litchford, Kevin Sung, Rebecca Hutcheson, Joshua Marceau, Taylor Johnson, Akinobu Ota, Nell E. Baumgarten, Michael Gale, Julie M. Overbaugh

This study uses CRISPR-Cas9 to identify LY6E as an antiviral factor against coronaviruses in respiratory cells.

bioRxiv · Sep 23, 2026 · PreprintMicrobiology

The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2

Jamie Guenthoer, Meghan E. Garrett, Michelle Lilly, Delphine Depierreux, Felicitas Ruiz, Margaret Chi, Caitlin I. Stoddard, Vrasha Chohan, Zak A. Yaffe, Kevin Sung, Duncan Ralph, Helen Y. Chu, Frederick A. Matsen IV, Julie M. Overbaugh

This paper identifies diverse functional antibodies targeting the S2 subunit of SARS-CoV-2 spike, including one with broad neutralization activity across multiple coronaviruses.

PLoS Pathogens · Aug 2, 2024Peer-reviewedImmunology

ATP hydrolysis by the SNF2 domain of the ultraspecific maintenance methylase Dnmt5 drives recognition and modification of hemimethylated DNA

Phillip A. Dumesic, Caitlin I. Stoddard, Sandra Catania, Geeta J. Narlikar, Hiten D. Madhani

The paper shows that ATP hydrolysis by the SNF2 domain of Dnmt5 is coupled to DNA methylation, enhancing substrate specificity through base-flipping mechanisms.

bioRxiv · Jan 5, 2020 · PreprintMolecular Biology

Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de novo methyltransferase

Sandra Catania, Phillip A. Dumesic, Harold Pimentel, Ammar Nasif, Caitlin I. Stoddard, Jordan E. Burke, Jolene K. Diedrich, Sophie L. Cooke, Terrance Shea, Elizabeth Gienger, Robert E. Lintner, John R. Yates, Petra Hájková, Geeta J. Narlikar, Christina A. Cuomo, , Hiten D. Madhani

The paper shows that DNA methylation persists in Cryptococcus neoformans despite the loss of a de novo methyltransferase, with methylation patterns maintained through replication and natural selection.

Cell · Jan 1, 2020Peer-reviewedMolecular Biology