Author

Akinobu Ota

Aichi Medical UniversityORCID 0000-0002-6296-2921Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Yoshitaka HosokawaiD· 3 shared Hiroyuki KonishiiD· 2 shared Md Lutfur RahmaniD· 2 shared Md WahiduzzamaniD· 2 shared Shinobu TsuzukiiD· 2 shared Sivasundaram KarnaniD· 2 shared Toshinori HyodoiD· 2 shared Yohei OkadaiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Yoshitaka HosokawaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 23, 2026

A knockout screening platform for interferon-stimulated genes in respiratory cells identifies LY6E as a dominant antiviral effector against coronaviruses

Caitlin I. Stoddard, Morgan L. Litchford, Kevin Sung…·Julie M. Overbaugh

This study uses CRISPR-Cas9 to identify LY6E as an antiviral factor against coronaviruses in respiratory cells.

DOI 10.64898/2026.09.21.751853

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Cancer BiologyCell Death and DiseasePeer-reviewedFeb 28, 2026

Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A-deficient malignant pleural mesothelioma

Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan…·Yoshitaka Hosokawa

This study identifies FASN inhibition as a therapeutic strategy for NF2/CDKN2A-deficient MPM, showing reduced tumor growth in xenograft models.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 13, 2025

Early pathogenesis of spinal and bulbar muscular atrophy uncovered by human iPSC-derived motor neurons highlights pathogenic neuropeptides as therapeutic targets

Kazunari Onodera, Yuichi Riku, Daisuke Shimojo…·Yohei Okada

The paper uses human iPSC-derived motor neurons to study SBMA, identifying neuropeptides as therapeutic targets.

DOI 10.64898/2025.12.10.692869

humanbulk RNA-seq

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Molecular BiologyCell ReportsPeer-reviewedJan 1, 2020

Tandem paired nicking promotes precise genome editing with scarce interference by p53

Toshinori Hyodo, Md Lutfur Rahman, Sivasundaram Karnan…·Hiroyuki Konishi

This study introduces tandem paired nicking, a genome editing method that minimizes indels and p53 activation while maintaining knock-in efficiency.

40 citations

experimental assay

𝕏 PostBluesky