A c-di-AMP-controlled glutamine synthesis pathway promotes persistence of Staphylococcus aureus thymidine-dependent small colony variants in the lung
Joshua P. Leeming, Shoukai Kang, Pearl P. Thakkar, Pratyusha Gorige, Devanshi R. Patel, Yuxin Pan, Oscar Villasana‐Espinosa, Daniel J. Wolter, Cara C. Boutte, Qing Tang
This study identifies a c-di-AMP-controlled glutamine synthesis pathway critical for survival of Staphylococcus aureus TD-SCVs in the thymidine-limited CF lung.
bioRxiv · Jul 31, 2026 · PreprintMicrobiology