Oncogenic Ppm1d mutations deregulate the p53 pathway in primary mouse gliomas
Vennesa Valentine, Adam Groth, Joshua Tolliver, Avneesh Saravanapavan, Spencer M. Maingi, Loren B. Weidenhammer, Nerissa T. Williams, Lixia Luo, Matthew S. Waitkus, Sheeba Jacob, Zachary J. Reitman
This study develops a mouse model of Ppm1d mutations in gliomas, showing they deregulate the p53 pathway, promote gliomagenesis, and increase radiosensitivity and PARP inhibitor vulnerability.
Neuro-Oncology Pediatrics · Mar 16, 2026Peer-reviewedGenetics