Author

Avneesh Saravanapavan

Duke UniversityORCID 0009-0003-8839-463XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Adam GrothiD· 1 shared Alan D. D’AndreaiD· 1 shared Erfan RahmaniiD· 1 shared Geoffrey Ira ShapiroiD· 1 shared Guang‐Li ZhuiD· 1 shared Huy Q. NguyeniD· 1 shared Joshua Tolliver· 1 shared Lifang SuniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Adam GrothORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedAug 14, 2026

Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors

Guang‐Li Zhu, Shuhei Asada, Huy Q. Nguyen…·Alan D. D’Andrea

This study identifies a defect in MMEJ repair in SMARCB1-deficient tumors, leading to hyper-dependence on the FA/BRCA pathway, which can be targeted for therapy.

1 citation

humanexperimental assay

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GeneticsNeuro-Oncology PediatricsPeer-reviewedMar 16, 2026

Oncogenic Ppm1d mutations deregulate the p53 pathway in primary mouse gliomas

Vennesa Valentine, Adam Groth, Joshua Tolliver…·Zachary J. Reitman

This study develops a mouse model of Ppm1d mutations in gliomas, showing they deregulate the p53 pathway, promote gliomagenesis, and increase radiosensitivity and PARP inhibitor vulnerability.

DOI 10.1093/neuped/wuag012

mousebulk RNA-seq

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