Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity
Marissa M. Bivins, Joshua Tomberg, Madeleine Bagshaw, Avinash Kumar Singh, Sandeepchowdary Bala, Christopher Davies, Robert A. Nicholas
This study identifies key mutations in PBP2 from a ceftriaxone-resistant Neisseria gonorrhoeae strain that balance resistance and transpeptidase activity.
bioRxiv · Nov 13, 2025 · PreprintMicrobiology