Christopher Davies

Energetic coupling of an active site residue in penicillin-binding protein 2 from Neisseria gonorrhoeae with a resistance-associated conformational switch in the β3-β4 loop

This study investigates how Tyr422 in PBP2 couples ligand recognition to conformational changes in the β3-β4 loop, revealing energetic coupling mechanisms underlying ceftriaxone resistance in Neisseria gonorrhoeae.

A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae

This paper identifies a novel benzoxaborinine-based inhibitor (VNRX-14079) that effectively targets penA-mediated resistance in multidrug-resistant Neisseria gonorrhoeae.

Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity

This study identifies key mutations in PBP2 from a ceftriaxone-resistant Neisseria gonorrhoeae strain that balance resistance and transpeptidase activity.