Cell BiologybioRxiv
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Ching-Chieh Chou, Ryan Vest, Miguel A. Prado…·Judith Frydman
This study uses transdifferentiated neurons to show lysosomal deficits are an early event in aging and Alzheimer's disease, leading to proteotoxic deposits and cell death.
DOI 10.1038/s41556-025-01623-y