Author

Jian Luo

VA Palo Alto Health Care SystemORCID 0000-0002-2064-8467Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jian Luo1 paper · University of Dundee

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrew C. YangiD· 3 shared Patricia Morán LosadaiD· 3 shared Tony Wyss‐CorayiD· 3 shared Andreas KelleriD· 2 shared Ian Hunter GuldneriD· 2 shared Nannan LuiD· 2 shared Ning-Sum To· 2 shared Pui Shuen Wong· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Andrew C. YangORCID

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3 papers

Recent·Most cited

Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia

Ian Hunter Guldner, Viktoria Wagner, Patricia Morán Losada, Sophia M. Shi, Kelly S. Chen, Barbara T Meese, Hamilton Se‐Hwee Oh, Yann Le Guen, Nannan Lu, Pui Shuen Wong, Ning-Sum To, Dylan T. Garceau, Zimin Guo, Jian Luo, Michael Sasner, , Tony Wyss‐Coray

The paper identifies neuronal proteins that degrade slower with aging and accumulate in microglia, linking impaired synaptic protein turnover to age-related cognitive decline.

bioRxiv · May 20, 2025 · PreprintNeuroscience

Circulatory proteins shape microglia state and boost phagocytosis

Nannan Lu, Patricia Morán Losada, Oliver Hahn, Aryaman Saksena, Emma Tapp, Jean Paul Chadarevian, Wentao Dong, Sophia M. Shi, Steven R. Shuken, Ian Hunter Guldner, Wenshu Zeng, Ning-Sum To, Pui Shuen Wong, Jonathan Hasselmann, Hayk Davtyan, , Tony Wyss‐Coray

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

bioRxiv · Sep 30, 2024 · PreprintNeuroscience

A human brain vascular atlas reveals diverse cell mediators of Alzheimer's disease risk

Andrew C. Yang, Ryan T. Vest, Fabian Kern, Davis P. Lee, Christina A. Maat, Patricia Morán Losada, Michelle B. Chen, Maayan R. Agam, Nicholas Schaum, Nathalie Khoury, Kruti Calcuttawala, Róbert Pálovics, Andrew Shin, Elizabeth Y Wang, Jian Luo, , Tony Wyss‐Coray

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.

bioRxiv · Apr 26, 2021 · PreprintNeuroscience