Mechanical force regulates the inhibitory function of PD-1
Hui Chen, Yong Zhang, Lei Cui, Juan Fan, Huaying Zhu, Songfang Wu, Hang Zhou, Yanruo Zhang, Guangtao Song, Ning Jenny Jiang, Mingzhao Zhu, Changjie Lou, Wei Chen, Jizhong Lou
This study shows that PD-1 ligand interactions are force-dependent and soluble PD-L1 can block PD-1, suggesting new approaches for cancer immunotherapy.
EMBO Reports · Feb 25, 2026Peer-reviewedBiophysics