Wei Chen

Intrinsic immune receptor triggering mechanism informs rational chimeric receptor design

The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.

PD-1 remodels SHP2 dynamics and drives the non-catalytic inhibition of T cell activation

This study reveals that PD-1 remodels SHP2 dynamics to inhibit T cell activation through a non-catalytic mechanism, independent of its phosphatase activity.

Mechanical force regulates the inhibitory function of PD-1

This study shows that PD-1 ligand interactions are force-dependent and soluble PD-L1 can block PD-1, suggesting new approaches for cancer immunotherapy.

CD28 Co-stimulation Is Organized by Signaling Condensates and Counteracted by PD-1

This study shows CD28 co-stimulation forms signaling condensates with Lck, which PD-1 modulates by binding and disrupting these structures, leading to engineered CAR T cells with improved antitumor activity.

Artificial-Cell-Type Aware Cell Type Classification in CITE-seq

CITE-sort improves cell type classification in CITE-seq by addressing artificial cell types caused by multiplets, achieving better clustering performance than existing methods.