Single-cell phylodynamics reveal rapid late-stage colorectal cancer expansions
João M. Alves, Kylie Chen, Sonia Prado‐Lòpez, Nuria Estévez‐Gómez, Pilar Alvariño, Juana Alonso, Monica Vishnu Valecha, Laura Tomás, Antoine Zwaans, Ugnė Stolz, Tanja Stadler, Débora Chantada, José Cameselle‐Teijeiro, Alexei J. Drummond, David Posada
The paper uses single-cell whole-genome sequencing and Bayesian phylodynamic modeling to show colorectal tumors often originate decades before diagnosis and expand rapidly in the last two years.
bioRxiv · Nov 25, 2025 · PreprintEvolutionary Biology